Publication: Prevalence and determinants of atrial fibrillation progression in paroxysmal atrial fibrillation

Atrial fibrillation is a disease that progresses from self-terminating short-lasting episodes  to more frequent episodes, long-lasting non-self-terminating episodes.

The progression of atrial fibrillation is of importance because it is associated with increased risk of cardiovascular morbidity and mortality and decreased quality of life.

Bao-Oanh Nguyen and colleagues, under the supervision of prof. dr. Isabelle Van Gelder and prof. dr. Michiel Rienstra developed a clinical atrial fibrillation progression risk prediction model using extensive phenotyping and continuous rhythm monitoring in patients with self-terminating short-lasting episodes.

The analysis wass performed in the Reappraisal of AF: Interaction Between HyperCoagulability, Electrical Remodelling, and Vascular Destabilisation in the Progression of AF (RACE V) study

They found that clinical predictors for atrial fibrillation progression included:

  • markers of atrial cardiomyopathy,
  • higher waist circumference, and
  • male sex.

Moreover, adding cardiovascular biomarkers improved the risk prediction model. The cardiovascular biomarkers that improved the model were:

  • atrial remodelling,
  • inflammation, atherosclerosis, and
  • coagulation.

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