Pablo Ignacio Sánchez Aguilera

PhD Student

Pablo is from Chile and he arrived to the Netherlands with his wife to perform a Sandwich PhD program between the University of Chile and the UMCG. They will stay for two years, therefore they are open to learn from the Dutch people all they have to show them. He likes the nature very much and would like to get to know the surroundings of Netherlands and meet its culture and language. As a foreign visitor he would like to make a new circle of friends that make my wife and me feel like at home.

Current activities

His project can be divided in two parts: 1 titled “Role of Mitochondrial Calcium Uniporter (MCU) in the IGF-1-induced cardiomyocyte hypertrophy” developed in neonatal cardiomyocytes; 2 will be developed in the UMCG and will be study the role of IF1 and its impact on the heart’s response to several challenges.

My projects

KETONE-HF

Harnessing the power of ketones

MITO-FORCE

MITOchondrial therapy to increase cardiac FORCE and enhance exercise performance

My publications

ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ

Mario G Pavez-Giani, Pablo I Sánchez-Aguilera, Nils Bomer, Shigeki Miyamoto, Harmen G Booij, Paula Giraldo, Silke U Oberdorf-Maass, Kirsten T Nijholt, Salva R Yurista, Hendrik Milting, Peter van der Meer, Rudolf A de Boer, Joan Heller Brown, Herman W H Sillje, B Daan Westenbrink. Int. J. Mol. Sci. 2021.

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Membrane Cholesterol in Skeletal Muscle: A Novel Player in Excitation-Contraction Coupling and Insulin Resistance.

Barrientos G, Sánchez-Aguilera P, Jaimovich E, Hidalgo C, Llanos P. J Diabetes Res. 2017

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ccentric resistance training reduces both non-response to exercise and cardiovascular risk factors in adult with overweight or obesity.

Díaz-Vegas A, Espinoza A, Cofré C, Sánchez-Aguilera P. EScience & Sports. 2017

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Role of ABCA1 on membrane cholesterol content, insulin-dependent Akt phosphorylation and glucose uptake in adult skeletal muscle fibers from mice.

Sánchez-Aguilera P, Diaz-Vegas A, Campos C, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2018

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