Annet Linders

PhD Student

I received both my bachelor’s (Biomedical Sciences, 2015) and master’s degree (Regenerative Medicine and Technology, 2018) from the University of Utrecht. The bachelor’s program included an exchange to the National University of Singapore, and during the master the first internship was spend with Joost Sluijter’s experimental cardiology lab at the UMC Utrecht. The second internship was with Ibrahim Domian’s cardiology lab at Massachusetts General Hospital in Boston. During this last internship, I came in contact with prof. dr. Peter van der Meer, where I started my PhD program in 2018.

Contact details

Current activities

Recently, cancer survival has increased dramatically, leading to the discovery that most treatment strategies for this disease have toxic effects in other parts of the body, in particular the heart. I am studying the molecular pathways involved in this cardiotoxicity, using induced pluripotent stem cell derived cardiomyocytes from patients.

It is expected that Annet will defend her thesis in 2024.

My projects


Stem cell models to unravel the susceptibility and resilience to develop heart failure

My publications

Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues

view on PubMed

Metabolic Maturation of Human Pluripotent Stem Cell Derived Cardiomyocytes by Inhibition of HIF1α and LDHA.

Hu D, Linders A, Yamak A, Correia C, Kijlstra JD, Garakani A, Xiao L, Milan DJ, van der Meer P, Serra M, Alves PM, Domian IJ. Circulation Research. 2018

view on publisher site