Kirsten Nijholt and Daan Westenbrink studied the role of AKIP1 in physiological stress and the study was recently published online in Scientific Reports. Other contributors to study were P. Sánchez-Aguilera, H. Booij, S. Oberdorf-Maass, M. Dokter, A. Wolters, B. Giepmans, W van Gilst, J. Brown, R. de Boer and H. Silljé.
While the cell signalling pathways related to pathological cardiac hypertrophy are rather well-described, little is known about the pathways involved in physiological cardiac hypertrophy. The authors therefore investigated the influence of the signalling adaptor AKIP1 on the response to voluntary exercise in a murine model.
Results show that AKIP1 promotes cardiomyocyte elongation and physiological cardiac remodelling through activation of two distinct signalling pathways: namely the Akt-C/EBP-CITED4 and the RSK3-PP2Ac-SRF pathways. Therefore, AKIP1 may serve as a potential therapeutic target to stimulate physiological cardiac growth in a pathological setting, such as heart failure.