Dr. Aboumsallem is currently a postdoctoral fellow at the experimental cardiology for the cardio-oncology project SECRETE-HF.
He was awarded his Doctoral Degree in Biomedical Sciences from the Catholic University of Leuven. The main focus of his PhD work has been on lipoprotein-targeted therapies and drug discovery for heart failure (HF). Further, he established several animal models of HF.
He earned his Master’s Degree in Genomics and Health and acquired a solid understanding of genomics and its applications in human diseases, and particularly in cancer. He explored the correlation between iron metabolism and breast cancer.
Joseph Pierre is involved in SECRETE-HF and focuses on the bidirectional communication between cancer and HF. The project aims to explore the effects of the secreted factors from failing hearts on organ dysfunction and tumors. This involves clinically relevant animal models, target findings, several disciplines (proteomics, metabolomics, extracellular vesicles profiling), and deep phenotyping of clinical databases.
Secreted factors in cardiac remodeling provoke tumorigenesis and end organ damage in heart failure