Bernadet Santema


After I graduated from medical school in Utrecht, I started working as a clinical doctor at the Department of Cardiology of the Jeroen Bosch Hospital (‘s Hertogenbosch). In this year, I learned that I was really passionate about the field of cardiology, and became truly motivated to eventually becoming a clinical cardiologist. Soon after starting my PhD-program at the UMCG, I realized that I was working with an extremely enthusiastic and unique team of heart failure scientists. Therefore, I am grateful that at our department, I get the opportunity to continue my scientific work with becoming a heart failure specialist.

Contact details

Current activities

My aim is to investigate sex differences in the treatment of heart failure, and to better understand the close pathophysiological link between sex, atrial fibrillation and heart failure, which could lead to better detection, understanding, and personalized treatment of patients in this vicious circle.

My projects


Facilitate personalized therapies in patients with heart failure

My publications

The influence of atrial fibrillation on the levels of NT-proBNP versus GDF-15 in patients with heart failure.

Santema BT, Chan MMY, Tromp J, Dokter M, van der Wal, H H, Emmens JE, Takens J, Samani NJ, Ng LL, Lang CC, van der Meer P, Ter Maaten JM, Damman K, Dickstein K, Cleland JG, Zannad F, Anker SD, Metra M, van der Harst P, de Boer RA, van Veldhuisen DJ, Rienstra M, Lam CSP, Voors AA. Clin Res Cardiol. 2019

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Comparing biomarker profiles of patients with heart failure: atrial fibrillation vs. sinus rhythm and reduced vs. preserved ejection fraction.

Santema BT, Kloosterman M, Van Gelder IC, Mordi I, Lang CC, Lam CSP, Anker SD, Cleland JG, Dickstein K, Filippatos G, Van der Harst P, Hillege HL, Ter Maaten JM, Metra M, Ng LL, Ponikowski P, Samani NJ, Van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, Van der Meer P, Rienstra M, Voors AA. Eur Heart J 2018

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Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study.

Santema BT, Ouwerkerk W, Tromp J, Sama IE, Ravera A, Regitz-Zagrosek V, Hillege H, Samani NJ, Zannad F, Dickstein K, Lang CC, Cleland JG, Ter Maaten JM, Metra M, Anker SD, van der Harst P, Ng LL, van der Meer P, van Veldhuisen DJ, Meyer S, Lam CSP, ASIAN-HF investigators, Voors AA. Lancet 2019

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